VIGABATRIN AND DEPRESSION

RING, HA

doi:10.1136/jnnp.56.8.925

1993-08-01

RING, HA

R. F. Crellin

E. H. Reynolds

DOI：10.1136/jnnp.56.8.925

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摘要

En 中文

Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.

Keyword:

GAMMA-VINYL GABA

PLASMA GABA

DISORDERS

EPILEPSY

ILLNESS

CSF

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期刊

Journal of Neurology Neurosurgery and Psychiatry

IF:

7.5

论文数:

1.9W

被引数:

3.3W

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