.png){kind=icon}
返回
Virtual memory CD8 T cells display unique functional properties
.png){kind=icon}
OA
AI
DOI：10.1073/pnas.1307572110.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8 T cells in unimmunized mice. Considerable evidence suggests this population, termed virtual memory (VM) CD8 T cells, arise via physiological homeostatic mechanisms. However, the antigen-specific function of VM cells is poorly characterized, and hence their potential contribution to immune responses against pathogens is unclear. Her ewe show that naturally occurring, polyclonal VM cells have unique functional properties, distinct from either naive or antigen-primed memory CD8 T cells. In striking contrast to conventional memory cells, VM cells showed poor T cell receptor-induced IFN-gamma synthesis and preferentially differentiated into central memory phenotype cells after priming. Importantly, VM cells showed efficient control of Listeria monocytogenes infection, indicating memory-like capacity to eliminate certain pathogens. These data suggest naturally arising VM cells display unique functional traits, allowing them to form a bridge between the innate and adaptive phase of a response to pathogens.
Keyword:
homeostasis
lymphocyte
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
P
IF:
9.1
论文数:
10.8W
被引数:
73.5W
机构
暂无机构信息
引用论文
CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa miceCD8 T调节细胞表达Ly49 I类MHC受体，并且在自身免疫性B6-Yaa小鼠中存在缺陷OAAI
OAAI分享收藏Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexesOAAI
OAAI分享收藏The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells.png)
NATURE IMMUNOLOGY
NATURE IMMUNOLOGYIF27.6
PREAI
分享收藏
查看更多内容