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Vitamin K2 (MK-7) as a novel cytoprotective agent in ovarian ischemia–reperfusion: Promoting functional recovery
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DOI：10.1016/j.tice.2026.103571.png)
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Abstract
En 中文
• MK-7 reduces ovarian ischemia-reperfusion injury by lowering oxidative stress. • Vitamin K2 treatment suppresses pro-inflammatory cytokines and NF-κB expression. • MK-7 prevents apoptosis in ovarian tissue by downregulating BAX and Caspase-3. • Follicular structure and AMH levels are maintained through SIRT1/BCL-2 regulation. • MK-7 is a promising therapeutic candidate for managing ovarian injury.
Keywords:
Vitamin K2
ovarian ischemia-reperfusion
oxidative stress
inflammation
apoptosis
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