.png){kind=icon}
返回
Voltage mapping in subcellular nanodomains using electro-diffusion modeling
.png){kind=icon}
PRE
AI
DOI：10.1063/5.0215900.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Voltage distribution in sub-cellular micro-domains such as neuronal synapses, small protrusions, or dendritic spines regulates the opening and closing of ionic channels, energy production, and thus, cellular homeostasis and excitability. Yet how voltage changes at such a small scale in vivo remains challenging due to the experimental diffraction limit, large signal fluctuations, and the still limited resolution of fast voltage indicators. Here, we study the voltage distribution in nano-compartments using a computational approach based on the Poisson-Nernst-Planck equations for the electro-diffusion motion of ions, where inward and outward fluxes are generated between channels. We report a current-voltage (I-V) logarithmic relationship generalizing Nernst law that reveals how the local membrane curvature modulates the voltage. We further find that an influx current penetrating a cellular electrolyte can lead to perturbations from tens to hundreds of nanometers deep, depending on the local channel organization. Finally, we show that the neck resistance of dendritic spines can be completely shunted by the transporters located on the head boundary, facilitating ionic flow. To conclude, we propose that voltage is regulated at a subcellular level by channel organization, membrane curvature, and narrow passages.
Keyword:
ELECTRODIFFUSION
PLASTICITY
DENDRITES
TIME
期刊
IF:
3.1
论文数:
7.2W
被引数:
23.2W
机构
引用论文
分享收藏Deconvolution of Voltage Sensor Time Series and Electro-diffusion Modeling Reveal the Role of Spine Geometry in Controlling Synaptic Strength.png)
NEURON
OAAI
NEURONIF15
OAAI分享收藏Trends in the Prevalence of Methicillin-Resistant Staphylococcus aureus Associated With Discontinuation of an Isolation Policy耐甲氧西林金黄色葡萄球菌流行趋势与隔离政策终止的关联
PREAI
分享收藏
查看更多内容