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Well ordered-microstructure bioceramics
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DOI：10.1016/j.apmt.2021.101194.png)
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It is a great challenge to endow the bioceramics with the bone-matched mechanical performances. Here, capturing inspiration from well ordered-microstructures in the high-performance natural composites, we propose a universal biomineralization-assembly-sintering approach for the fabrication of well ordered microstructure meta-hydroxyapatite. Owing to the well ordered-microstructure and a new metal ions related interface toughening mechanism, this well ordered-microstructure hydroxyapatite exhibits remarkable mechanical performances, which are far beyond those of existing hydroxyapatite-based bioceramic and totally matched with the human cortical bone. Furthermore, the ordered microstructure plays a significant role in modulating the cell fates and finally stimulating bone defects regeneration in vivo . This work not only provides a strategy for the fabrication of well ordered-microstructure bioceramic but also broadens the horizons for the interface toughening mechanism of composites and microstructure design of biomaterials for bone regeneration. (c) 2021 Elsevier Ltd. All rights reserved.
Keyword:
Bioceramics
Well ordered-microstructure
Mechanical performances
Biological performances
期刊
IF:
6.9
论文数:
3.4K
被引数:
1.6W
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