When imaging meets size-transformable nanosystems

Yang Zhou

doi:10.1016/j.addr.2022.114176

2022-04-01

PRE

DOI：10.1016/j.addr.2022.114176

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摘要

En 中文

Imaging techniques, including magnetic, optical, acoustic and nuclear imaging, are gaining popularity as a research tool and clinical diagnostics. The advent of imaging agents-incorporated nanosystems (NSs), with sufficient contrast and high resolution, facilitates better monitoring of disease progression, targeted delivery and therapeutic process. Of note, the size of NSs remarkably affects imaging performance, while both large and small NSs enjoy respective features and superiority for imaging aspect, including penetra-tion depth, signal-to-background ratio and spatiotemporal resolution. In this review, after a systematic summary of the basic knowledge of imaging techniques and its relation with size-tunable strategies, we further provide insights into the opportunities and challenges facing size-transformable NSs of the future for bio-imaging application and clinical translation.(c) 2022 Elsevier B.V. All rights reserved.

Keyword:

Size-transformable nanosystems

Stimulus activation

Imaging

Magnetic resonance imaging

Photoacoustic imaging

Fluorescence imaging

期刊

Advanced Drug Delivery Reviews

IF:

17.6

论文数:

4.5K

被引数:

5.1W

机构

russian academy of sciences

学者数:

9.1W

论文数: 6.0W

被引数: 60

sichuan university

学者数:

12.1W

论文数: 7.8W

被引数: 100

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