When membrane proteins prefer lipids

doi:10.1038/s41589-025-02084-y

2025-11-28

PRE

Edward Lyman *

DOI：10.1038/s41589-025-02084-y

原文链接

原文求助

摘要

En 中文

膜蛋白的功能依赖于脂质环境，但这是否归因于高亲和力、配体样连接尚不清楚。广泛的分子动力学模拟和单分子FRET测量现在表明，氯离子转运蛋白的二聚化实际上是由一种优先溶剂化机制控制的。

Keyword:

membrane proteins

lipid environment

molecular dynamics simulations

single-molecule FRET

preferential solvation

期刊

Nature Chemical Biology

IF:

13.7

论文数:

4.8K

被引数:

3.3W

机构

University of Delaware

学者数:

1.3W

论文数: 1.3W

被引数: 2.0W

引用论文

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers 脂质双层中CLC转运蛋白二聚化的热力学分析

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-10-03

OAAI

Chadda, Rahul; Lee, Taeho; Kruszka, Robyn Mahoney; Kelley, Elizabeth G.; Bernhardt, Nathan; Sandal, Priyanka; Robertson, Janice L.

Preferential solvation and the selectivity of lipid-protein interactions

Biophysical Journal

IF0

1995-09-01

OAAI

D. Marsh

Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2002-07-03

662

OAAI

Timasheff, SN

Extension of the theory of linked functions to incorporate the effects of protein hydration 链接功能理论的扩展，以纳入蛋白质水合作用的影响

Journal of Molecular Biology

IF0

1969-02-01

PREAI

Charles Tanford

Activation of G-protein-coupled receptors is thermodynamically linked to lipid solvation

BIOPHYSICAL JOURNAL

IF3.1

2021-05-01

OAAI

Leonard, Alison N.; Lyman, Edward

Molecular basis for the regulation of membrane proteins through preferential lipid solvation 膜蛋白通过选择性脂质溶合作用的分子调控机制

Nature Chemical Biology

IF13.7

2025-09-26

OAAI

Nathan Bernhardt; Tugba N. Ozturk; Shan Zhang; Noah Schwartz; Rahul Chadda; Alejandro Gil-Ley; Janice L. Robertson; José D. Faraldo-Gómez

没有更多内容