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Wnt/OPG signaling axis drives ectopic mandibular regeneration: Mechanism mediated by tibial periosteal stem cell sheets

delete2026-04-23
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PRE
AI
L
Liangchong Huang
R
Rongju Xie
J
Jiantong Pu
S
Shengjie Shao *
W
Weihong Wang *
DOI：10.1016/j.tice.2026.103542delete
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Abstract

Abstract

En 中文
• Tibial and mandibular periosteum show distinct osteogenic gene expression profiles. • Tibial PSC sheets enhance mandibular bone repair via Wnt signaling activation. • Dual mechanisms of Wnt-osteogenesis and OPG-anti-resorption drive regeneration.
Keywords:
Wnt signaling
OPG
periosteal stem cells
bone regeneration
osteogenic gene expression

Journal

Tissue and Cell cover
Tissue and Cell
IF:
2.5
Papers:
867
Citations:
4.1K

Organization

K
Kunming Medical University
Scholars:
1.5K
Papers: 419
Citations: 7.9K
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