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Young-onset multiple system atrophy
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DOI：10.1016/j.jns.2012.04.016.png)
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Background: Multiple system atrophy (MSA) rarely begins before the age of 40 and detailed descriptions of young-onset MSA are lacking. Methods: Among 455 patients included in our MSA cohort, four developed disease before the age of 40. We reviewed the medical records of these patients. Results: Case 1 and 2 presented with cerebellar symptoms. Case 1 had clinical features and a course typical of MSA. Case 2 had a rapid course and died 3 years after onset. Case 3 and Case 4 presented with levodoparesponsive parkinsonism. Both developed motor fluctuations and peak-dose limb dyskinesias. Subthalamic deep brain stimulation (DBS) resulted in some improvements in motor symptoms, but they became totally dependent within a few years. Discussion: Young-onset MSA is rare but does exist. Young-onset MSA with predominant parkinsonism may closely resemble Parkinson disease at onset and is likely to develop motor complications. Attention should be given to the possibility of young-onset MSA in selecting DBS candidates. (C) 2012 Elsevier B.V. All rights reserved.
Keyword:
Multiple system atrophy
Young-onset
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