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ZnONPs/Cs/Fic/FA for overcoming multidrug-resistant infections and enhanced wound-healing
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DOI：10.1016/j.jiec.2026.03.002.png)
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Abstract
En 中文
Global healthcare faces severe challenges from multidrug-resistant (MDR) bacterial biofilms. This study developed a targeted ZnONPs/Cs/Fic/FA nanosystem, integrating the zinc oxide (ZnO) nanoparticles (NPs) core with chitosan (Cs) and ficin (Fic), followed by folic acid (FA). Following the comprehensive structural characterization (FT-IR, XRD, and TEM), the prepared nanosystem demonstrated superior antibacterial potency against four major pathogens, including A. baumannii and S. aureus. The key results showed Minimum Inhibitory Concentrations (MIC) as low as 6.07 µg mL−1 and inhibition zones up to 25 mm, notably outperforming the conventional antibiotics, i.e., ciprofloxacin. Also, the nanosystem achieved ∼90% biofilm inhibition and exhibited high biocompatibility in anti-hemolytic assays. Under in vivo trials confirmed significantly accelerated and complete wound closure compared to individual components. These findings established the ZnONPs/Cs/Fic/FA as a powerful, multi-modal nanosystem for treating resistant infections and enhancing the infected tissue repair.
Keywords:
ZnONPs/Cs/Fic/FA
multidrug-resistant bacteria
biofilm inhibition
wound healing
nanosystem
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