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Zongyangia acetica sp. nov. and Blautia acetica sp. nov., two acetate-producing bacteria isolated from human fecal in the order Eubacteriales
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DOI：10.1016/j.syapm.2026.126696.png)
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Abstract
En 中文
Two gram-stain positive, non-motile, spore-forming and anaerobic bacterial strains that are designated as HA2173T and HA2174T were isolated from the faeces of an adult woman. Physiological and biochemical analyses revealed that both strains are neutrophilic, mesophilic, and tolerant to low concentrations of NaCl. Analysis of 16S rRNA gene sequences indicated that strains HA2173T and HA2174T belonged to the families Oscillospiraceae and Lachnospiraceae, respectively. The phylogenetic relatives closest to strains HA2173T and HA2174T were Zongyangia hominis NSJ-54T (16S rRNA gene similarity is 97.7%) and Blautia argi N6H1-15T (16S rRNA gene similarity is 97.9%), respectively. Genome annotation indicated that both strains could metabolize carbohydrates and generate propionate, acetate and formate, and the major end-products of fermentation of both strains HA2173T and HA2174T were determined to be acetic acid. The major polar lipids detected in strain HA2173ᵀ were diphosphatidylglycerol and phosphatidylglycerol, but only diphosphatidylglycerol was identified in strain HA2174ᵀ. Cohort analysis revealed divergent prevalence patterns for strains HA2173ᵀ and HA2174ᵀ, with their relative abundances significantly elevated in the T2D and OB cohorts. Based on the results of phylogenetic analysis, 16S rRNA gene similarity, and chemotaxonomic characteristics, strains HA2173T and HA2174T represent novel species of the genus Zongyangia and Blautia, respectively, for which the names Zongyangia acetica sp. nov. and Blautia acetica sp. nov. are proposed. The type strain for Zongyangia acetica sp. nov. is HA2173T (=CGMCC 1.18038T = KCTC 25723T). The type strain for Blautia acetica sp. nov. is HA2174T (=CGMCC 1.18039T = KCTC 25724T)
Keywords:
Zongyangia acetica
Blautia acetica
acetate-producing bacteria
16S rRNA gene
human fecal microbiota
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