.png){kind=icon}
.png){kind=icon}
Return
Zwitterionic Granular Hydrogel for Cartilage Tissue Engineering
.png){kind=icon}
OA
AI
M
F
P
D
M
DOI：10.1002/adhm.202301831.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Zwitterionic hydrogels have high potential for cartilage tissue engineering due to their ultra-hydrophilicity, nonimmunogenicity, and superior antifouling properties. However, their application in this field has been limited so far, due to the lack of injectable zwitterionic hydrogels that allow for encapsulation of cells in a biocompatible manner. Herein, a novel strategy is developed to engineer cartilage employing zwitterionic granular hydrogels that are injectable, self-healing, in situ crosslinkable and allow for direct encapsulation of cells with biocompatibility. The granular hydrogel is produced by mechanical fragmentation of bulk photocrosslinked hydrogels made of zwitterionic carboxybetaine acrylamide (CBAA), or a mixture of CBAA and zwitterionic sulfobetaine methacrylate (SBMA). The produced microgels are enzymatically crosslinkable using horseradish peroxidase, to quickly stabilize the construct, resulting in a microporous hydrogel. Encapsulated human primary chondrocytes are highly viable and able to proliferate, migrate, and produce cartilaginous extracellular matrix (ECM) in the zwitterionic granular hydrogel. It is also shown that by increasing hydrogel porosity and incorporation of SBMA, cell proliferation and ECM secretion are further improved. This strategy is a simple and scalable method, which has high potential for expanding the versatility and application of zwitterionic hydrogels for diverse tissue engineering applications. A novel zwitterionic granular hydrogel is introduced for cartilage defect repair. The hydrogel is injectable, allows for direct cell encapsulation, and undergoes in situ enzymatic crosslinking to provide mechanical stability of the construct. This novel hydrogel combines biocompatibility and nonimmunogenicity of zwitterionic materials with versatility and microporosity of granular hydrogels, expanding zwitterionic hydrogels applications in tissue engineering. image
Keywords:
carboxybetaine acrylamide
cartilages
granulars
hydrogels
injectable hydrogels
microgels
zwitterionic hydrogels
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
9.6
Papers:
7.5K
Citations:
4.4W
Organization
Cited Papers