α2δ-1 regulates synaptic AMPA receptor trafficking and LTP through distinct pre- and postsynaptic functions

Gerardo Leana-Sandoval

doi:10.1016/j.nbd.2026.107553

α2δ-1 regulates synaptic AMPA receptor trafficking and LTP through distinct pre- and postsynaptic functions

2026-07-30

0

OA

AI

G

Gerardo Leana-Sandoval

M

Matthew A. Sandoval

A

Ananth V. Kolli

E

Emily Saavedra

K

Kathy H. Li

A

Alma L. Burlingame

J

Jorge Ramírez‐Franco

J

Javier Díaz-Alonso *

DOI：10.1016/j.nbd.2026.107553

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Abstract

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• The VGCC auxiliary subunit α2δ-1 is a putative GluA1 ATD interacting protein. • Postsynaptic α2δ-1 deletion increases basal synaptic AMPAR transmission. • Presynaptic α2δ-1 deletion reduces LTP without altering basal synaptic transmission.

α2δ-1 regulates synaptic AMPA receptor trafficking and LTP through distinct pre- and postsynaptic functions

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