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27P silk bioactive peptides mediate multifaceted regulation of collagen and support balance in fibroblast subpopulations
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DOI：10.1016/j.biocel.2025.106821.png)
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Abstract
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Fibroblasts play a key role in maintaining skin structure and immune balance, but factors like aging, stress, and chronic inflammation can weaken their function, leading to collagen loss, thinning skin, and increased inflammation. Traditional collagen boosters like retinoic acid (RA), vitamin C (VC), hyaluronic acid (HA), and transforming growth factor beta (TGFβ) have drawbacks, including poor absorption, instability, and irritation.
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