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3D-printed MOF–hydrogel microarray for multiplexed miRNA detection and early herb-induced liver injury warning
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DOI：10.1016/j.bios.2026.119000.png)
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Abstract
En 中文
• Novel 3D-printedMOF-hydrogel microarray (3D-MHMA) for multiplexed miRNA detection. • The platform integrates MOF-based enrichment/quenching with a CHA-HCR cascade for ultrasensitive, enzyme-free amplification. • We first validated miR-194 as an early-warning biomarker with miR-122 for herb-induced liver injury (HILI). • Platform demonstrated superior early diagnostic capability in vivo and in vitro.
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