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3D printed Zn-Cu alloy bone scaffolds via nanoparticle incorporation: Microstructural evolution and enhanced mechanical-antimicrobial-osteogenic properties
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DOI：10.1016/j.matdes.2025.115390.png)
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Abstract
En 中文
• A high-speed centrifugal stirring method was developed to uniformly disperse and attach nano-Cu particles onto Zn powder, preserving powder integrity and enabling elemental homogeneity. • LPBF facilitated in-situ precipitation of semi-coherent ε-CuZn5 phases within ultra-refined equiaxed grains. This microstructure yielded significantly improved mechanical properties. • The scaffold demonstrated an optimized corrosion rate within the ideal range for bone healing, ensuring both stability and biofunctionality. • The scaffold demonstrated controlled Zn2+ / Cu2+ co-release kinetics, significantly enhancing in vitro osteogenic differentiation and exhibiting potent broad-spectrum antibacterial activity. • The in vivo experiments confirmed that the scaffold exhibits enhanced osteogenic properties.
Keywords:
Bone defect repair
Biodegradable metal scaffolds
Osteogenesis
Antibacterial properties
3D printing
Material incorporation
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