3D RGO@MoS2/Ag NPs based SERS platform for label-free detection of IL-6

2026-03-20

PRE

Qinqin Qian

Haocheng He

Songyin Fu

Jia Xu

Ho-Pui Ho

Shuwen Zeng

江滔 (Tao Jiang)

Sheqin Lv *

Chenjie Gu *

DOI：10.1016/j.matchemphys.2026.132416

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Abstract

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• A surface-enhanced Raman scattering substrate consisting of reduced graphene oxide encapsulated in molybdenum disulfide with additional Ag nanoparticles (Ag NPs) decorated on the surface was developped. • The developed RGO@MoS2/Ag NPs SERS substrate enables the highly sensitive, label-free detection of IL-6. • The developed SERS substrate achieves a detection limit as low as 10-9 M, with an enhancement factor of 2.2 × 109. • The SERS substrate detected IL-6 with a good linear response in the 5.0–1000 pg/mL range and a detection limit as low as 0.41 pg/mL.

Keywords:

SERS substrate

IL-6 detection

reduced graphene oxide

molybdenum disulfide

silver nanoparticles

3D RGO@MoS2/Ag NPs based SERS platform for label-free detection of IL-6

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