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6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation

delete2026-03-18
delete0
PRE
AI
J
Jialin Yu
H
Hao Zhang
M
Meiyao Li
S
Shanshan Chen
W
Wei Shi *
DOI：10.1016/j.neuron.2026.02.028delete
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Abstract

Abstract

En 中文
• 6-OHDA suppresses mouse mammary tumor growth beyond sympathetic nerve ablation • 6-OHDA induces cancer cell IFN-β production in a cGAS-dependent manner • 6-OHDA-induced IFN-β promotes the generation of pro-inflammatory ISG+ macrophages • ISG+ macrophages support TH1 cell-mediated antitumor immunity
Keywords:
6-OHDA
mammary tumor
IFN-β
macrophage remodeling
antitumor immunity

Journal

Neuron cover
Neuron
IF:
15
Papers:
1.4W
Citations:
9.9W

Organization

P
Peking Union Medical College
Scholars:
1.8W
Papers: 1.4W
Citations: 20
C
Capital Medical University
Scholars:
5.3W
Papers: 3.3W
Citations: 3.2W
C
chinese academy of medical sciences and peking union medical college
Scholars:
5.2K
Papers: 1.3K
Citations: 0
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