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A 1 Hz multipoint multispectral confocal microscope
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DOI：10.1016/j.optlastec.2026.115084.png)
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Abstract
En 中文
Multispectral imaging is a powerful technique that can detect subtle differences in the fluorescence expression of a species based on its reaction to its environment. These subtle differences offer a powerful contrast agent that can be used to identify new compounds for novel medicines. A high spectral resolution is crucial for this approach, since small changes in a species’ spectral signature can indicate meaningful changes within the local environment. Multispectral confocal imaging is slow because single-point confocal techniques have fundamental signal collection limitations, and currently, no massively multiplexed measurement technique offers high-resolution simultaneous multispectral measurement. Multiplexing with a window scanning multipoint confocal microscope, offers new spatially encoded spectral measurements on dense image sensors by sweeping spectral bands with a dedicated window scanner. We present a 32x32 point multiplexed confocal microscope that captures 22 spectral bands simultaneously at a real-time image frequency of 1 Hz over the entire spectral range of 450 nm to 650 nm.
Keywords:
Confocal microscopy
Hyperspectral imaging
Multispectral
Multiplexing
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