A class of anti-inflammatory lipids decrease with aging in the central nervous system

doi:10.1038/s41589-022-01165-6

A class of anti-inflammatory lipids decrease with aging in the central nervous system

2022-10-20

6

OA

AI

DOI：10.1038/s41589-022-01165-6

Original

Original request for help

Save

Abstract

En 中文

Lipids contribute to the structure, development, and function of healthy brains. Dysregulated lipid metabolism is linked to aging and diseased brains. However, our understanding of lipid metabolism in aging brains remains limited. Here we examined the brain lipidome of mice across their lifespan using untargeted lipidomics. Co-expression network analysis highlighted a progressive decrease in 3-sulfogalactosyl diacylglycerols (SGDGs) and SGDG pathway members, including the potential degradation products lyso-SGDGs. SGDGs show an age-related decline specifically in the central nervous system and are associated with myelination. We also found that an SGDG dramatically suppresses LPS-induced gene expression and release of pro-inflammatory cytokines from macrophages and microglia by acting on the NF-kappa B pathway. The detection of SGDGs in human and macaque brains establishes their evolutionary conservation. This work enhances interest in SGDGs regarding their roles in aging and inflammatory diseases and highlights the complexity of the brain lipidome and potential biological functions in aging.

Keywords:

RAT-BRAIN

NEURODEGENERATIVE DISEASE

IN-VIVO

INFLAMMATION

MYELIN

BIOSYNTHESIS

METABOLISM

EXPRESSION

PATHWAYS

MOUSE

A class of anti-inflammatory lipids decrease with aging in the central nervous system

Abstract

Journal

Organization