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A complex systems perspective on psychedelic brain action
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DOI：10.1016/j.tics.2023.01.003.png)
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Abstract
En 中文
Recent findings suggesting the potential transdiagnostic efficacy of psychedelic -assisted therapy have fostered the need to deepen our understanding of psyche-delic brain action. Functional neuroimaging investigations have found that psychedelics reduce the functional segregation of large-scale brain networks. However, beyond this general trend, findings have been largely inconsistent. We argue here that a perspective based on complexity science that foregrounds the distributed, interactional, and dynamic nature of brain function may render these inconsistencies intelligible. We propose that psychedelics induce a mode of brain function that is more dynamically flexible, diverse, integrated, and tuned for information sharing, consistent with greater criticality. This 'meta' perspective has the potential to unify past findings and guide intuitions toward compelling mechanistic models.
Keywords:
NEURONAL AVALANCHES
PREFRONTAL CORTEX
5-HT2A RECEPTORS
NETWORK
CONNECTIVITY
CRITICALITY
ACTIVATION
PSILOCYBIN
SEROTONIN
STATE
Journal
IF:
17.2
Papers:
3.6K
Citations:
3.5W
Organization
Cited Papers
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.png)
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