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A conductive antibacterial composite film containing chopped fibers and ciprofloxacin loaded PCL particles for wound dressing application
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DOI：10.1007/s10856-026-07092-5.png)
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Abstract
En 中文
Designing multifunctional wound dressings with admirable mechanical virtues, appropriate electrical conductivity, and good antibacterial performance is critical for preventing infection and promoting tissue repair. Herein, a conductive gellan–agar composite film reinforced with chopped PCL–gelatin electrospun fibers containing polyaniline–graphene (PAG) and loaded with ciprofloxacin (Cip)–encapsulated PCL particles, was developed. The highest electrical conductivity (5.6 × 10–5 S.cm–1) was donated to the PCL-gelatin fibers with 1.5 wt.% PAG. The conductive film revealed desirable mechanical characteristics including tensile strength (8.51 ± 0.06 MPa) and elastic modulus (5.92 ± 0.09 MPa) by addition of PCL-gelatin-1.5 wt.% PAG chopped fibers, indicating effective reinforcement of the hydrogel-based matrix. Moreover, the system enabled sustained Cip release, and the release kinetics was well described by a first-order model. The developed film demonstrated antibacterial activity against both Gram-positive and Gram-negative strains, showing inhibition zones of 9 ± 3 mm for Staphylococcus aureus and 16 ± 1 mm for Escherichia coli. In addition, the film displayed appropriate swelling and degradation behavior, supporting its suitability as a wound-contact dressing. The developed multifunctional film in this research would be a worthy asset to prevent infection and accelerate wound repair in future studies.
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