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A continuous-discrete model of cell contraction incorporating actin and intermediate filaments

delete2026-06-05
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OA
AI
S
Soheil Sarbishei
Y
Yousef Javanmardi *
R
Reza Azarbad
M
Morteza Naeij
P
Pradeep Keshavanarayana
E
Emad Moeendarbary *
F
Fabian Spill *
DOI:10.1016/j.isci.2026.116279delete
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Abstract

Abstract

En 中文
• A continuous-discrete model captures actin and intermediate filament dynamics • Actin filaments accumulate near focal adhesions and the plasma membrane • Intermediate filaments resist excessive deformation during cell contraction • Model predictions agree with experimental membrane curvature measurements
Keywords:
Biological sciences
Biochemistry
Cell biology
Integrative aspects of cell biology
Functional aspects of cell biology
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