A critical review of brain entropy as a biomarker of the psychedelic state

Bruno Moses

doi:10.1016/j.neubiorev.2026.106720

A critical review of brain entropy as a biomarker of the psychedelic state

2026-04-28

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B

Bruno Moses

M

Manoj K. Doss

E

Enzo Tagliazucchi *

DOI：10.1016/j.neubiorev.2026.106720

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Abstract

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• We review the use of brain entropy as a biomarker of the psychedelic state • We identify key practical and conceptual difficulties with entropy-based biomarkers • We propose refinements to overcome these limitations in future research

Keywords:

brain entropy

psychedelic state

biomarker

neural dynamics

consciousness research

A critical review of brain entropy as a biomarker of the psychedelic state

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