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A distribution-guided Mapper algorithm

delete2025-03-05
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AI
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Yuyang Tao
S
Shufei Ge *
DOI:10.1186/s12859-025-06085-5delete
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Abstract

Abstract

En 中文
BackgroundThe Mapper algorithm is an essential tool for exploring the data shape in topological data analysis. With a dataset as an input, the Mapper algorithm outputs a graph representing the topological features of the whole dataset. This graph is often regarded as an approximation of a Reeb graph of a dataset. The classic Mapper algorithm uses fixed interval lengths and overlapping ratios, which might fail to reveal subtle features of a dataset, especially when the underlying structure is complex.ResultsIn this work, we introduce a distribution-guided Mapper algorithm named D-Mapper, which utilizes the property of the probability model and data intrinsic characteristics to generate density-guided covers and provide enhanced topological features. Moreover, we introduce a metric accounting for both the quality of overlap clustering and extended persistent homology to measure the performance of Mapper-type algorithms. Our numerical experiments indicate that the D-Mapper outperforms the classic Mapper algorithm in various scenarios. We also apply the D-Mapper to a SARS-COV-2 coronavirus RNA sequence dataset to explore the topological structure of different virus variants. The results indicate that the D-Mapper algorithm can reveal both the vertical and horizontal evolutionary processes of the viruses. Our code is available at https://github.com/ShufeiGe/D-Mapper.ConclusionThe D-Mapper algorithm can generate covers from data based on a probability model. This work demonstrates the power of fusing probabilistic models with Mapper algorithms.
Keywords:
Topology data analysis
Mapper
Mixture model
Extended persistence

Journal

BMC Bioinformatics cover
BMC Bioinformatics
IF:
3.3
Papers:
594
Citations:
5.2W

Organization

No organization information available
Cited Papers

Cited Papers

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Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development
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errRizvi, Abbas H.; Camara, Pablo G.; Kandror, Elena K.; Roberts, Thomas J.; Schieren, Ira; Maniatis, Tom; Rabadan, Raul
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Cluster Analysis
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Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion
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errPlanas, Delphine; Staropoli, Isabelle; Michel, Vincent; Lemoine, Frederic; Donati, Flora; Prot, Matthieu; Porrot, Francoise; Guivel-Benhassine, Florence; Jeyarajah, Banujaa; Brisebarre, Angela; Dehan, Oceane; Avon, Lea; Bolland, William Henry; Hubert, Mathieu; Buchrieser, Julian; Vanhoucke, Thibault; Rosenbaum, Pierre; Veyer, David; Pere, Helene; Lina, Bruno; Trouillet-Assant, Sophie; Hocqueloux, Laurent; Prazuck, Thierry; Simon-Loriere, Etienne; Schwartz, Olivier
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