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A drug-free hyaluronic acid and modified carboxymethyl cellulose double cross-linked multifunctional hydrogel wound dressing
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DOI：10.1016/j.jmbbm.2026.107508.png)
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Abstract
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• A dual-crosslinked OHA/PVA/HCMC hydrogel was designed through hydrazide bonds and hydrogen bonds. • The synergistic effect of NaHCO3 and hyaluronic acid endows the hydrogel with potent antibacterial activity. • The hydrogel promoted fibroblast proliferation and migration, demonstrating excellent biocompatibility. • This antibiotic-free, mechanically robust hydrogel shows high potential for infected wound healing.
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