A dual-function interleukin-1 receptor couples bacterial recognition to MyD88-dependent NF-κB activation during antibacterial immunity in shrimp

2026-08-13

PRE

Siyou Huang

Wanli Lu

Yuxin Shi

Tao Lin

Xueer Tang

Song Guo

Xinhua Chen

Linwei Yang *

DOI：10.1016/j.fsi.2026.111650

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Abstract

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• IL-1R directly recognizes Gram-positive and Gram-negative bacteria in shrimp. • IL-1R links extracellular pathogen sensing to MyD88–Dorsal/NF-κB signaling. • IL-1R plays a critical role in antibacterial defense against Vibrio infection.

Keywords:

Penaeus vannamei

Interleukin-1 receptor

MyD88

Dorsal

Innate immunity

Vibrio parahaemolyticus

A dual-function interleukin-1 receptor couples bacterial recognition to MyD88-dependent NF-κB activation during antibacterial immunity in shrimp

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