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A dual-mode ECL/SERS biosensor for sensitive and self-validated detection of APE1 via X-shaped DNA-triggered cascade amplification and a perovskite–Au/MXene interface
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DOI：10.1016/j.snr.2026.100490.png)
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Abstract
En 中文
• A dual-mode ECL/SERS biosensor was developed for sensitive APE1 detection. • An X-shaped DNA recognizer enabled efficient APE1-triggered cascade amplification. • A PAM interface integrated ECL emission and plasmon-enhanced Raman readout. • APE1 induced opposite ECL decrease and SERS increase for self-validation.
Keywords:
APE1
Electrochemiluminescence
Surface-enhanced Raman scattering
Dual-mode biosensor
Strand displacement amplification
MXene-perovskite hybrid
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