A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan+ non-classical monocytes

Michael Hertwig

doi:10.1016/j.jaut.2026.103579

A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan+ non-classical monocytes

2026-06-13

0

PRE

AI

M

Michael Hertwig

S

Stephanie Oehrl

T

Thomas Döbel

H

Hao Zhang

S

Stefan Meisel

A

Amelie List

K

Knut Schäkel *

DOI：10.1016/j.jaut.2026.103579

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• We discover that SlanMo have the capacity to migrate along a gradient of ICs. • This IC-induced, gradient-dependent directed migration is not shared by other leukocyte subtypes. • FcγRIII (CD16) is of primary importance for high-affinity binding of IC and the induction of directed migration. • Phosphoproteomic analysis of migrating SlanMo, identified ROCK, Lyn, crk, FAK, and moesin as relevant signaling proteins. • Transcriptomic studies on migrating SlanMo reveal a lupus-associated activation signature.

A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan+ non-classical monocytes

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