A hybrid mechanistic-data-driven framework for knowledge-driven and experiment-efficient HPLC method development

doi:10.1016/j.chroma.2026.467379

A hybrid mechanistic-data-driven framework for knowledge-driven and experiment-efficient HPLC method development

2026-08-29

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Maximilian O. Besenhard *

DOI：10.1016/j.chroma.2026.467379

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Abstract

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• Hybrid mechanistic-data-driven HPLC method optimisation. • Framework for intelligent autonomous HPLC. • Significant reduction in experimental effort.

Keywords:

Hybrid mechanistic–data-driven modelling

Mechanistic modelling

Data-driven optimisation

Autonomous HPLC method development

Digital HPLC twin

A hybrid mechanistic-data-driven framework for knowledge-driven and experiment-efficient HPLC method development

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