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A Janus-type polycaprolactone/chitosan scaffold with dual functions of leakage prevention and osteogenesis for skull base defect repair
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DOI：10.1016/j.bioadv.2026.215092.png)
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Abstract
En 中文
• Janus bilayer scaffold prevents CSF leakage and promotes bone regeneration. • Porous simvastatin/HA layer induces osteogenesis and hemostasis. • Electrospun PCL layer provides sealing. • In vivo: enhanced bone formation and effective leakage prevention.
Keywords:
Skull base repair
Leakage prevention
Asymmetric structure
Chitosan
Hydroxyapatite
Bilayer scaffold
Journal
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6
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1.9K
Citations:
6.0K
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