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A landscape analysis of human SUMOylation
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DOI：10.1016/j.mcpro.2026.101571.png)
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Abstract
En 中文
• We generated a Human SUMO build: 35,721 sites across 6,146 proteins. • SUMOylated lysines are 2.4× more likely to occur in intrinsically disordered regions. • Exclusively SUMOylated and ubiquitinated sites occupy structurally distinct regions. • Sites co-modified by SUMO and ubiquitin show the highest disease variants proportion. • Non-SUMOylated negative set extracted from the same experimental peptide pool.
Keywords:
false localization rate
human SUMO proteome
computational proteomics
mass spectrometry
SUMOylation
PTM
post-translational modification
MS
mass spectrometry
TPP
Trans-Proteomic Pipeline
FLR
false localization rate
SUMO
Small Ubiquitin-like MOdifier
SCMs
SUMO consensus motifs
GO
Gene Ontology
PSMs
peptide-spectrum matches
m/z
mass-to-charge
EBV
Epstein-Barr virus
SIOD
Schimke immuno-osseous dysplasia
PDSM
phosphorylation-dependent SUMOylation motif
USI
Universal Spectrum Identifier
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