.png){kind=icon}
.png){kind=icon}
Return
A living biobank of sarcoma patient-derived cell cultures reveals multi-omic and functional insights that capture disease heterogeneity
.png){kind=icon}
OA
AI
S
S
D
S
F
C
F
N
K
J
K
P
J
P
J
A
G
G
O
DOI：10.1002/ctm2.70722.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Sarcomas are rare, diverse malignancies with limited therapeutic options and poor clinical outcomes. Preclinical models that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. We established and comprehensively characterized 29 early-passage patient-derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes. Multi-region and multi-site sampling enabled generation of PDCs from spatially distinct areas of individual tumours and from matched primary, recurrent and metastatic lesions.
Keywords:
biobank
drug screening
functional assays
patient-derived cell cultures
sarcoma
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.8
Papers:
2.6K
Citations:
9.6K
Organization
Cited Papers