Comparison of Clinical Characterization and Therapeutic Strategies between Homozygous Familial Hypercholesterolemia and Heterozygous Familial Hypercholesterolemia

D Shishikura

doi:10.5551/jat.65959

A Low LDL-C Level but not Statin Use is Associated with In-hospital Mortality in Spontaneous Intracerebral Hemorrhage; The J-ICH Registry

2026-03-01

0

PRE

AI

K

Kazo Kanazawa

M

Miyamoto, Nobukazu *

H

Hideaki Ueno

T

Tsutsumi, Satoshi

R

Rikizo Saito

J

Joji Tokugawa

Y

Yuji Ueno

Y

Yamashiro, Kazuo

M

Munetaka Yamamoto

Y

Yukimasa Yasumoto

M

Makoto Hishii

T

Takuji Yamamoto

C

Chikashi Maruki

T

Takao Urabe

K

Kondo, Akihide

H

Hajime Arai

N

Nobutaka Hattori

R

Ryota Tanaka *

DOI：10.5551/jat.65992

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Abstract

En 中文

Aim: A reduction in low-density lipoprotein cholesterol (LDL-C) is beneficial for vascular diseases; however, lower LDL-C levels may be associated with an increased risk of spontaneous intracerebral hemorrhage (sICH). The present study investigated the relationship between the LDL-C levels and in-hospital mortality after sICH using data from the Juntendo Registry of Spontaneous Intra-Cerebral Hemorrhage (J-ICH registry). Methods: Patients aged >= 20 years with non-traumatic sICH admitted to five Juntendo-affiliated hospitals between September 2016 and December 2019 were enrolled in this study. The relationships between the LDL-C levels and in-hospital mortality, statin therapy, and antithrombotic therapy were analyzed. Results: Among the 1,017 patients with sICH, lower LDL-C levels were associated with older age, a lower BMI, a larger hematoma volume, more severe neurological deficits, and a higher in-hospital mortality. A logistic regression analysis confirmed that LDL-C < 100 mg/dL independently increased the risk of in-hospital death, along with age, the NIHSS score, hematoma volume, and intraventricular hemorrhage. Subgroup analyses showed that the association between low LDL-C levels and mortality was particularly evident in patients with deep/infratentorial intracerebral hemorrhage, those managed without surgery, and those without prior statin use. Prior statin use was associated with a potential protective effect against in-hospital mortality and hematoma volume. Conclusion: This study demonstrated that lower LDL-C levels were associated with a higher in-hospital mortality after sICH, whereas prior statin use was not associated with poorer outcomes and may instead offer a protective effect.

Keywords:

Low-density lipoprotein cholesterol

Intracerebral hemorrhage

In-hospital mortality

Statins

J-ICH registry

A Low LDL-C Level but not Statin Use is Associated with In-hospital Mortality in Spontaneous Intracerebral Hemorrhage; The J-ICH Registry

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