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A Microfluidic Ion Sensor Array
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DOI：10.1002/smll.201906436.png)
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Abstract
En 中文
A balanced concentration of ions is essential for biological processes to occur. For example, [H+] gradients power adenosine triphosphate synthesis, dynamic changes in [K+] and [Na+] create action potentials in neuronal communication, and [Cl-] contributes to maintaining appropriate cell membrane voltage. Sensing ionic concentration is thus important for monitoring and regulating many biological processes. This work demonstrates an ion-selective microelectrode array that simultaneously and independently senses [K+], [Na+], and [Cl-] in electrolyte solutions. To obtain ion specificity, the required ion-selective membranes are patterned using microfluidics. As a proof of concept, the change in ionic concentration is monitored during cell proliferation in a cell culture medium. This microelectrode array can easily be integrated in lab-on-a-chip approaches to physiology and biological research and applications.
Keywords:
bioelectronics
electrochemical biosensors
ion-selective electrodes
microfluidics
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