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A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia
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DOI：10.1016/j.phrs.2026.108361.png)
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Abstract
En 中文
• MSLED lowers serum urate and alleviates renal and intestinal injury in a stable diet-induced hyperuricemic rat model. • MSLED is associated with coordinated intestinal urate excretion, ABCG2/GLUT9 modulation, and barrier improvement. • Integrated multi-omics reveals coordinated metabolic-immune remodeling with IL-17/MAPK-associated inflammation.
Keywords:
ABCG2
ATP-binding cassette subfamily G member 2
ADA
adenosine deaminase
BenZ
benzbromarone
BUN
blood urea nitrogen
Ctrl
control
Crea
creatinine
DEGs
differentially expressed genes
GC-MS
gas chromatography-mass spectrometry
GLUT9
glucose transporter 9
HUA
hyperuricemia
HUD
hyperuricemia diet
IL
interleukin
KEGG
Kyoto Encyclopedia of Genes and Genomes
KO
KEGG orthology
LC-MS/MS
liquid chromatography-tandem mass spectrometry
LEfSe
linear discriminant analysis effect size
LPS
lipopolysaccharide
MAPK
mitogen-activated protein kinase
MSLED
Modified Shuilu Erxian Decoction
OPLS-DA
orthogonal partial least squares discriminant analysis
PCoA
principal coordinates analysis
PCA
principal component analysis
PPI
protein-protein interaction
PO
potassium oxonate
QPCR
quantitative polymerase chain reaction
RNA-seq
RNA sequencing
SCFAs
short-chain fatty acids
SUA
serum urate
TC
total cholesterol
TG
triglycerides
ULT
urate-lowering therapy
UA
uric acid
WB
Western blotting
XOD
xanthine oxidase
hyperuricemia
urate excretion
intestine
ABCG2
GLUT9
multi-omics
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