.png){kind=icon}
.png){kind=icon}
Return
A Multi-Switch Mechanism Underlying Mechanical Force Regulation of Aggrecan Degradation in Osteoarthritic Cartilage
.png){kind=icon}
PRE
AI
Y
S
DOI：10.1016/j.joca.2026.05.011.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Force modulates ADAMTS-5–aggrecan binding through multiple stabilization switches. • Stable binding states identified at 0, 100, 400, and 900 pN by molecular simulations. • Distinct residues mediate force-dependent binding via hydrogen bonds and salt bridges. • A multi-switch mechanism explains non-linear loading effects on aggrecan degradation. • Provides a molecular basis for protective vs. degradative roles of cartilage loading.
Keywords:
ADAMTS-5
aggrecan
mechanical force
osteoarthritis
molecular dynamics
Journal
IF:
9
Papers:
1.3W
Citations:
2.2W
Organization
Cited Papers