A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation

Huan Wang

doi:10.1016/j.colsurfb.2026.115763

A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation

2026-04-30

0

PRE

AI

H

Huan Wang

S

Sijia Lin

周晋 (Jin Zhou)

J

Jinyue Bi

Y

Yiming Wang

X

Xinpei Li

Q

Qian Yang

S

Shuying Wu

X

Xueyong Qi

S

Song Shen

J

Jin Cao *

DOI：10.1016/j.colsurfb.2026.115763

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Abstract

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• A phycocyanin-based nanoplatform integrates chemotherapy and immunotherapy. • Mn-PC-PTX induces pyroptosis and activates the cGAS–STING pathway. • Phycocyanin suppresses COX-2/PGE2/PD-L1–mediated immune evasion. • The nanoplatform remodels the tumor microenvironment and boosts T cell immunity. • Mn-PC-PTX achieves potent antitumor efficacy with minimal systemic toxicity.

Keywords:

phycocyanin

chemotherapy

immunotherapy

cGAS–STING pathway

tumor microenvironment

A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation

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