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A new role of class A HBV capsid assembly modulators in core protein dynamics and cccDNA replenishment
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DOI：10.1016/j.jcmgh.2026.101860.png)
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Abstract
En 中文
Current treatments of chronic hepatitis B are rarely curative. Capsid assembly modulators (CAMs) target capsid formation by the hepatitis B virus (HBV) core protein. Class A CAMs (CAM-A) induce abnormal core protein assembly but how they affect core protein dynamics and inhibit HBV replication is only partially understood.
Keywords:
hepatitis B virus
core protein
capsid
capsid assembly modulators
BID
twice daily
CAMs
capsid assembly modulators
cccDNA
covalently closed circular DNA
CC50
half maximal cytotoxic concentration
dpi
day post-infection
EC50
half maximal effective concentration
ETV
entecavir
HAP
heteroaryldihydropyrimidine
HBeAg
hepatitis B e antigen
HBsAg
hepatitis B surface antigen
HBV
hepatitis B virus
LMV
lamivudine
moi
multiplicity of infection
NAGE
native agarose gel electrophoresis
NES
nuclear export signal
NLS
nuclear localization signal
NUCs
nucleos(t)ide analogs
pgRNA
pregenomic RNA
PML-NBs
promyelocytic leukemia nuclear bodies
PHH
primary human hepatocytes
PPAs
phenylpropenamides
QD
once daily
qPCR
real-time PCR
rcDNA
relaxed circular DNA
RT
reverse transcriptase
SBAs
sulfamoylbenzamides
TDF
tenofovir disoproxil fumarate
uPA/SCID
urokinase-type Plasminogen Activator/Severe Combined Immunodeficiency
vp
enveloped DNA containing virus particles
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