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A Novel BODIPY-Dinitrophenylhydrazine “Off–On” Hypochlorite Ion Fluorescent Probe Based on ICT Mechanism
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PRE
AI
刘
R
X
J
L
Y
S
DOI：10.1002/bio.70556.png)
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Abstract
En 中文
Hypochlorite (ClO−) plays a crucial role as a significant biological substance in the body. In this work, a fluorescent probe BODIPY-DP was designed based on the ICT mechanism for the detection of ClO−, using BODIPY as the fluorophore group and a C=N double bond linked to 2,4-dinitrophenylhydrazine as the recognition group. The fluorescence intensity of the probe shows a good linear relationship with ClO− concentration, with a linear correlation coefficient (R2) of 0.9945 and a detection limit of 7.38 μM. BODIPY-DP was found to exhibit good selectivity toward ClO−. The fluorescence intensity increases rapidly within 30 s after the addition of ClO−. The spiked recoveries in the determination of ClO− concentration in the disinfectant solutions were found to range from 93.8% to 108.0%. BODIPY-DP exhibits favorable cytocompatibility and proves highly effective for the detection of exogenous ClO− in living HepG2 cells. The findings of this study provide a new means for revealing the role of ClO− in biological processes.
Keywords:
BODIPY
fluorescent probe
hypochlorite
ICT process
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