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A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice
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OA
AI
李
J
L
X
W
S
J
S
C
X
H
龚
K
H
F
邹
DOI：10.1016/j.jacbts.2025.101324.png)
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Abstract
En 中文
• We developed MiARS, a novel surgical technique enabling the precise induction of AR in mice, characterized by minimal invasiveness, high procedural survivability, and real-time modulation of regurgitation. • The MiARS mouse heart reproduces the clinical feature of AR, including eccentric hypertrophy, as well as structural and functional changes seen in AR. • Bioinformatics analysis in this model suggest that Ankrd1 may serve as a potential biomarker for AR-induced cardiac remodeling.
Keywords:
aortic regurgitation
eccentric hypertrophy
echocardiography
heart failure
mouse model
AA
aortic arch
AAo
ascending aorta
AR
aortic regurgitation
ECG
electrocardiogram
DEG
differentially expressed gene
EF
ejection fraction
HF
heart failure
HW/BW
heart weight to body weight ratio
IVS
interventricular septum
KEGG
Kyoto Encyclopedia of Genes and Genomes
LAW/BW
left atrial weight to body weight ratio
LV
left ventricular
LVID
left ventricular internal diameter
LW/BW
lung weight to body weight ratio
LVPW
left ventricular posterior wall
MiARS
minimally invasive aortic regurgitation surgery
RCCA
right common carotid artery
TAC
transverse aortic constriction
WGCNA
weighted gene co-expression network analysis
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