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A novel peptide from Periplaneta americana: Development of a long-acting formulation for ulcerative colitis therapy
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DOI：10.1016/j.bioadv.2026.214965.png)
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Abstract
En 中文
• Anti-inflammatory oligopeptide PAE-P6 isolated from Periplaneta americana extract shows efficacy in ulcerative colitis mice. • Thermosensitive liposome-in-gel enables rectal, colon-targeted and sustained peptide delivery. • Formulation improves peptide stability and local exposure, supporting long-acting therapy and compliance. • Treatment enhances anti-inflammatory mediators, restores tight junctions and mucin, and suppresses pro-inflammatory signals. • Provides a translatable platform for peptides requiring targeted, sustained delivery in ulcerative colitis.
Keywords:
Periplaneta americana
Peptides
Ulcerative colitis
Thermosensitive liposome gel
Sustained release
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1.9K
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6.0K
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