A Paper-based Colorimetric Biosensor for Small-Molecule Histamine Based on Synergistic Kinetic-Relay Aptamer Recognition and PtFe Nanozyme Signal Amplification

Hong Chen

doi:10.1016/j.snb.2026.140666

A Paper-based Colorimetric Biosensor for Small-Molecule Histamine Based on Synergistic Kinetic-Relay Aptamer Recognition and PtFe Nanozyme Signal Amplification

2026-08-09

0

PRE

AI

H

Hong Chen

W

Wen Zhu

Y

Yuyang Zhang

S

Shutong Zhang

J

Jiao Li

J

Jianan Sun

王

王赛 (Sai Wang) *

X

Xiangzhao Mao

DOI：10.1016/j.snb.2026.140666

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• SKRAP were designed for small molecules to solve affinity-kinetic trade-off. • PtFe bimetallic nanozyme with robust peroxidase-mimicking activity was synthesized. • SKRAP@PtFe complex was immobilized on CS/PEG-paper for colorimetric detection. • The paper-based biosensor enabled rapid histamine detection with a LOD of 2.21 nM. • Application was verified in real-world raw and processed seafood.

A Paper-based Colorimetric Biosensor for Small-Molecule Histamine Based on Synergistic Kinetic-Relay Aptamer Recognition and PtFe Nanozyme Signal Amplification

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