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A photoregulated DNA nanoflower for spatiotemporally controlled monitoring of adenosine triphosphate in living cells
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DOI：10.1016/j.aca.2026.346070.png)
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Abstract
En 中文
• A tumor-targeted, aptamer-based, photocleavable DNA nanoflower (TAPE) is constructed for spatiotemporally controlled imaging of intracellular ATP in living cells. • The system integrates AS1411 aptamer-based tumor targeting and cholesterol modification, achieving up to 98.5% uptake efficiency in cancer cells. • A photocleavable linker enables a dual-lock “UV + ATP” activation logic, effectively suppressing non-specific signals before light triggering. • TAPE allows selective monitoring of drug-induced ATP fluctuations in living tumor cells.
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