A pilot single-case longitudinal multi-omics of canine oral melanoma characterizes endogenous mutation patterns and radiotherapy-associated responses

Gunha Hwang

doi:10.1016/j.gene.2026.150281

A pilot single-case longitudinal multi-omics of canine oral melanoma characterizes endogenous mutation patterns and radiotherapy-associated responses

2026-06-24

0

PRE

AI

G

Gunha Hwang

S

Seung-Wan Woo

H

Hee Chun Lee

J

Jaemin Kim *

T

Tae-Sung Hwang *

DOI：10.1016/j.gene.2026.150281

Original

Original request for help

Save

Abstract

En 中文

• Longitudinal WGS and RNA-seq profiled radiation response in canine oral melanoma. • Pre-treatment tumor harbored cancer-associated mutations and structural variants. • Radiation therapy induced time-dependent immune, cytoskeletal, and stress responses. • Post-RT blood transcriptomes partially reflected systemic molecular responses.

A pilot single-case longitudinal multi-omics of canine oral melanoma characterizes endogenous mutation patterns and radiotherapy-associated responses

Abstract

Journal

Organization