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A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents
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DOI：10.1016/j.taap.2010.09.024.png)
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Abstract
En 中文
Effects of phenobarbital (PB) on the levels of serum thyroid hormones such as total thyroxine (T-4) and triodothyronine were examined in male mice hamsters rats and guinea pigs One day after the final administration of PB (80 mg/kg intrapentoneal once daily for 4 days) significant decreases in the levels of the serum total T-4 and free T-4 occurred in mice hamsters and rats while a significant decrease in the level of serum triodothyronine was observed in hamsters and rats among the animals examined In addition a significant decrease in the level of serum thyroid stimulating hormone was observed in only hamsters among the rodents examined Significant increases in the level and activity of hepatic T-4 UDP-glucuronosyltransferase (UGT1A) after the PB administration occurred in mice hamsters and rats while the increase in the amount of Mary [I-125]T-4-glucuromde after an intravenous injection of [I-125]T-4 to the PB-pretreated animals occurred only in rats In mice rats and hamsters but not guinea pigs PB pretreatment promoted the clearance of [I-125]T-4 from the serum led to a significant increase in the steady state distribution volumes of [I-125]T-4 and raised the concentration ratio (Kp value) of the liver to serum and the liver distribution of [I-125]T-4 The present findings indicate that the PB-mediated decreases in the serum T-4 level in mice hamsters and rats but not guinea pigs occur mainly through an increase in the accumulation level of T-4 in the liver (C) 2010 Elsevier Inc All rights reserved
Keywords:
Phenobarbital
UDP glucuronosyltransferase
Thyroxine
Rodent
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