A programmable DNAzyme molecular machine for dual-modal analysis of choline acetyltransferase activity in circulating tumor cells

Sucheng Chen

doi:10.1016/j.microc.2026.118181

A programmable DNAzyme molecular machine for dual-modal analysis of choline acetyltransferase activity in circulating tumor cells

2026-04-24

0

PRE

AI

S

Sucheng Chen

X

Xingyu Zhao

C

Caizhao Cheng

H

Haodong Fang

J

Jinglu Yao

Z

Zhiyong Guo

Y

Yufang Hu *

D

Di Wu *

卿

卿志和 (Zhihe Qing)

DOI：10.1016/j.microc.2026.118181

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Abstract

En 中文

• The DNAzyme molecular machine enables dual-modal signal generation. • Ag+ induces DNAzyme activation via conformational switching. • CoA regulates DNAzyme activity through competitive metal coordination. • ChAT activity is quantitatively profiled in circulating tumor cells. • Dynamic responses under choline and hypoxia reveal ChAT regulation.

Keywords:

DNAzyme

Choline acetyltransferase

Circulating tumor cells

Dual-modal signal

Metal coordination

A programmable DNAzyme molecular machine for dual-modal analysis of choline acetyltransferase activity in circulating tumor cells

Abstract

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