A programmed magnetic resonance tuning probe for tumor miRNA-21 imaging and drug release monitoring

M. Chen

doi:10.1016/j.cej.2026.180442

A programmed magnetic resonance tuning probe for tumor miRNA-21 imaging and drug release monitoring

2026-08-09

0

PRE

AI

M

M. Chen

X

Xueqi Li

Z

Zhen Zhang

H

Hao Zhang

X

Xingyu Chen

J

Jiali Wang *

K

Kai Xu *

G

Guohui Cheng *

DOI：10.1016/j.cej.2026.180442

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Abstract

En 中文

• A programmed activatable MRI probe for integrated tumor biomarker imaging and real-time drug release monitoring. • Enables a cascade of biomarker-triggered DNAzyme activation, therapeutic release, and amplified MRI signal recovery. • Establishes a quantitative linear relationship between the MRI signal amplification and the amount of drug released. • Paves the way for intelligent, self-reporting theranostics and personalized treatment guidance in image-guided therapy.

Keywords:

In vivo imaging

microRNA-21

magnetic resonance tuning

DNAzyme walker

Drug release monitoring

A programmed magnetic resonance tuning probe for tumor miRNA-21 imaging and drug release monitoring

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