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A regulatory T cell-biased IL-2 mutein inhibits the development of allergen-specific Th2 cells and allergic asthma
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DOI：10.1016/j.jaci.2026.07.017.png)
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Abstract
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• A regulatory T cell-biased IL-2 mutein, Fc.mut24, selectively expands and enhances Tregs, promoting a tolerogenic immune environment in the lung. • Prophylactic Fc.mut24 treatment prevents the development of allergen-specific Th2 cells and allergic airway inflammation; this protection requires Tregs and is maintained even after allergen rechallenge. • Fc.mut24 treatment of mice after allergen sensitization is unable to inhibit allergen-specific Th2 cells and attenuate allergic airway inflammation, demonstrating a crucial early window of Treg-mediated tolerance induction.
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