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A reusable 3D-printed dispersive solid-phase extraction device for precise quantification of estrogen metabolites in human serum by LC-MS/MS
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DOI：10.1016/j.microc.2026.119317.png)
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Abstract
En 中文
• LC–MS/MS workflow quantifies 13 endogenous estrogen metabolites in serum. • Device-based handling reduces operator variability in bioanalytical practice. • Ethanol desorption replaces chlorinated solvents.
Keywords:
Estrogen metabolomics
3D-printed extraction device
Dispersive solid-phase extraction
LC–MS/MS bioanalysis
Green sample preparation
Bioanalytical method validation
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